The Clinical Evaluation Research Unit (CERU) provides coordination services for several research projects ranging from multicentre randomized trials and observational studies to single centre dosing trials. Many of these trials include international collaborators that are experts in their respective fields of research.

Here is a list of some of the trials that we have acted as the coordinating center that have been completed:

Investigating the Gastro-pulmonary Route of Infection

Heyland DK, Drover J, MacDonald S, Novak F, Lam M. Effect of post-pyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: Results of a randomized controlled trial. Critical Care Med 2001;29:1495-1501.

Validation of the Canadian Clinical Practice nutrition Guidelines for Mechanically Ventilated Patients

Jain MK, Heyland DK, Dhaliwal R, Day A, Drover J, Keefe L, Gelula M. Dissemination of the Canadian Practice Guidelines for nutrition support: Results of a cluster randomized trial. Crit Care Med 2006(Sept):34:2362-9.

The VAP Study

Heyland DK, Cook D, Dodek P, Muscedere J, Day A for the Canadian Critical Care Trials Group. A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med 2006(Dec);355(25):2619-30.

Heyland DK, Dodek P, Muscedere J, Day A, Cook D. Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med 2008;36(3):737-744.

The REDOX Trial

Heyland DK, Muscedere J, Wischmeyer P, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG for the Canadian Critical Care Trials Group. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013;368(16):1489-1497. (PMID: 23594003)

The PEP uP Trial

Heyland DK, Murch L, Cahill N, McCall M, Muscedere J, Stelfox HT, Bray T, Tranquay T, Jiang X, Day AG. Enhanced protein-energy provision via the enteral route feeding protocol in critically ill patients (The PEP uP Protocol): Results of a cluster randomized trial. Crit Care Med 2013 Dec;41(12):2743-53 (PMID: 23982032)

The CANTREAT Trial

Albert M Williamson D, Muscedere J, Lauzier F, Rostein C, Kanji S, Jiang X, Hall M, Heyland DK. Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Impact of Antifungal Treatment: a randomized palcebo controlled pilot trial (CANTREAT Study). Intensive Care Med 2014 Sep:40(9):1313-22 (PMID: 24981955).

The OVATION Trial Pilot

Lamontagne F, Meade MO, Hébert PC, et al. Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial. Intensive Care Medicine 2016;42(4):542-50. doi: 10.1007/s001

The TOP-UP Trial Pilot

Wischmeyer PE, Hasselmann M, Kummerien C, et al. A randomized supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Critical Care 2017;21(1):142. doi: 10.1186/s13054-017-1736-8 

The NUTRIATE Trial

Deane AM., Lamontagen, F, Dukes GE., Neil D., Vasist L., Barton ME., Hacquoil K., Ou X., Richards D., Stelfox HT., Mehta S., Day AG., Chapman MJ., Heyland DK. Nutrition Adequacy Therapeutic Enhancement in the Critically Ill: A Randomized Double-Blind, placebo-Controlled Trial fo the Motilin Receptor Agonist Camicinal (GSK962040): JPEN 2017 December DOI:10:1002/jpen.1038

 Here is a list of some of the trials of which we are currently the coordinating center: (Please click on the name if you are interested in learning more about them)

IPACK HD

ECoM

SUSTAIN

IMPACT

RE-ENERGIZE

NEXIS

EFFORT

INS 2018

 

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